Increasing Incidence, but Lack of Seasonality, of Elevated TSH Levels, on Newborn Screening, in the North of England
نویسندگان
چکیده
Previous studies of congenital hypothyroidism have suggested an increasing incidence and seasonal variation in incidence, which may suggest nongenetic factors involved in aetiology. This study describes the incidence of elevated thyroid stimulating hormone (TSH) values in newborns, a surrogate for congenital hypothyroidism, measured as part of the screening programme for congenital hypothyroidism, over an eleven-year period (1994-2005), and assesses whether seasonal variation exists. All infants born in the Northern Region of England are screened by measuring levels of circulating TSH using a blood spot assay. Data on all 213 cases born from 1994 to 2005 inclusive were available. Annual incidence increased significantly from 37 per 100,000 in 1994 to a peak of 92.8 per 100,000 in 2003. There was no evidence of seasonal variation in incidence. The reasons for the increasing incidence are unclear, but do not appear to involve increasing exposure to seasonally varying factors or changes in measurements methods.
منابع مشابه
Effects of Thyroid Hormone (T4, T3 ), Bromocriptine And Triac on Inappropriate TSH Hypersecretion
Inappropriate TSH hypersecretion was diagnosed in a 34 years old woman. Earlier she had been treated by ablative therapy for hyperthyroidism. The present diagnosis was based on elevated basal serum TSH levels despite elevated serum free thyroid hormone level. Her TSH responses to TRH (peak value 240 mu/I) was high. Her albumin and prealbumin levels were normal. The serum TBG level, alpha subuni...
متن کاملCongenital hypothyroidism with delayed TSH elevation in low-birth-weight infants: incidence, diagnosis and management.
OBJECTIVE To evaluate the incidence of congenital hypothyroidism (CH) with delayed TSH elevation among low-birth-weight (LBW) newborns in North-Eastern Italy and to verify if they need a second or third screening. DESIGN Analysis of clinical and biochemical data of newborns affected by CH with delayed TSH elevation identified by neonatal screening. METHODS Data of all newborns with birth we...
متن کاملPrevalence of CH that identified in neonatal screening program in Mashhad health center 2011
Introduction: Congenital hypothyroidism is the most common endocrine disease and is a major cause of preventable mental retardation. In most cases, it seems quite natural born at birth with delayed diagnosis, complications will cause irreparable brain. Now almost all industrialized countries and many developing countries the newborn screening program to systematically do. Khorasan Province neon...
متن کاملمیزان شیوع هیپوتیروئیدی مادرزادی و افزایشگذرای TSH در استان یزد
Introduction: Congenital hypothyroidism is one of the most preventable causes of mental retardation. Worldwide, incidences vary from 1:3000 to 1:4000 and mean incidence in Iran is estimated to be 1:1000. Neonatal screening and early treatment within first 2 weeks of neonatal period can prevent neurocognitive deficits. We aimed to study the incidence of CH and increased levels of TSH in Yazd pro...
متن کاملCord blood thyrotropin screening for primary hypothyroidism on Caribbean island: a rapid communication.
Screening programs using determinations of serum thyroxine have demonstrated that congenital hypothyroidism occurs in one in 4,000 live births in North America. More than 90 percent of affected infants have primary hypothyroidism with elevated plasma thyrotropin (TSH) levels. Since the feasibility of newborn screening and incidence of congenital hypothyroidism in other less well developed areas...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2010 شماره
صفحات -
تاریخ انتشار 2010